SCHEMBL6501593

SCHEMBL6501593

CCOc1ccc(Cn2c(C)nc3c(C)cc(-c4cc(C(=O)O)ccn4)cc32)c(Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 14/20 0.44
KDM5B Q9UGL1 6/20 0.44
KDM2B Q8NHM5 5/20 0.44
KDM5A P29375 5/20 0.44
KMO O15229 1/20 0.39
DCTPP1 Q9H773 2/20 0.38
KDM4A O75164 1/20 0.35
NTRK1 P04629 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6487673 0.92 JMJD6 (0.41) KDM4CKDM5BKDM2BKDM5ADCTPP1
SCHEMBL6488966 0.89 RXRA (0.41) DCTPP1
SCHEMBL6494714 0.89 KDM4C (0.44) KDM4CKDM5BKDM2BKDM5AKMO
SCHEMBL6488103 0.88 P4HTM (0.40) DCTPP1
SCHEMBL6488456 0.88 DCTPP1 (0.44) DCTPP1
SCHEMBL6489353 0.85 PIK3C2B (0.38) DCTPP1NTRK1
SCHEMBL6489346 0.82 MRGPRX4 (0.46)
SCHEMBL6489130 0.82 MAPT (0.40) DCTPP1
SCHEMBL6491045 0.82 DCTPP1 (0.42) DCTPP1
SCHEMBL6497678 0.82 PTPN11 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050014812-A1 Benzimidazole compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2005-01-20 US disclosed
WO-2004108686-A2 BENZIMIDAZOLE COMPOUNDS HAVING HYPOGLYCEMIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-12-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050014812-A1 Benzimidazole compounds SLC5A1, SLC5A2, G6PD KDM4C 443/4885KDM5B 551/4885KDM2B 378/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.