Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157490 | 0.82 | EPHX2 (0.53) | TSHREPHX2KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL6284656 | 0.78 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL5403510 | 0.78 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL12057492 | 0.78 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL7422735 | 0.78 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL15307926 | 0.78 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL2848716 | 0.78 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL5158011 | 0.78 | HSD11B1 (0.51) | EPHX2KMT2ASMN1; SMN2NPC1LMNA | |
| SCHEMBL8237595 | 0.77 | SMN1; SMN2 (0.58) | KMT2ASMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL13114591 | 0.77 | SMN1; SMN2 (0.58) | KMT2ASMN1; SMN2NPC1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CHENG HENGMIAO | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261290-A1 | Novel compounds of proline and morpholine derivatives | CYP11B1, HSD11B1, CYP11B2 | TSHR 2376/4885EPHX2 2185/4885KMT2A 3470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.