Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | LIG1 | P18858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502410 | 0.98 | OPRM1 (0.41) | OPRM1OPRL1OPRK1HDAC1OPRD1 | |
| SCHEMBL10476543 | 0.91 | OPRM1 (0.48) | OPRM1OPRL1OPRK1HDAC1OPRD1 | |
| Hydrochloric Acid SCHEMBL1141355 | 0.89 | OPRM1 (0.47) | OPRM1OPRL1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL28631532 | 0.82 | HDAC3 (0.40) | OPRM1OPRL1OPRK1HDAC1POLB | |
| SCHEMBL11091107 | 0.81 | HSD11B1 (0.41) | OPRM1OPRL1OPRK1SLC6A4SLC6A3 | |
| SCHEMBL8353019 | 0.81 | OPRM1 (0.43) | OPRM1OPRL1OPRK1HDAC1SMN1; SMN2 | |
| SCHEMBL17320610 | 0.79 | HDAC1 (0.38) | OPRM1HDAC1OPRD1ALDH1A1SLC6A4 | |
| SCHEMBL7262204 | 0.79 | SLC6A3 (0.53) | OPRM1OPRL1OPRK1HDAC1SLC6A4 | |
| SCHEMBL294583 | 0.78 | OPRM1 (0.63) | OPRM1OPRL1OPRK1SLC6A4 | |
| SCHEMBL8284914 | 0.78 | SLC6A3 (0.56) | OPRM1OPRL1OPRK1HDAC1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | BAYER HEALTHCARE AG (DE) | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | PPARD, PPARG, PPARA | OPRM1 2605/4885OPRL1 1716/4885OPRK1 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.