Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.66 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2604953 | 0.75 | BACE1 (0.61) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2604927 | 0.75 | MAPT (0.61) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6498396 | 0.75 | MAPT (0.61) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6495751 | 0.75 | CYP1A2 (0.49) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2604947 | 0.75 | KDM4E (0.55) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9332051 | 0.75 | NFE2L2 (0.54) | RIOK2CYP1A2CYP3A4KDM4EHPGD | |
| SCHEMBL2604931 | 0.74 | CYP1A2 (0.61) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11670985 | 0.73 | KDM4E (0.56) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11670988 | 0.73 | KDM4E (0.56) | MTNR1AMTNR1BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL26259281 | 0.72 | MAPT (0.60) | KDM4EHPGDMAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6846830-B2 | Naphtalene derivatives and their pharmaceutical use | ELI LILLY AND COMPANY (US) | 2005-01-25 | — | — | US | disclosed |
| US-20030073725-A1 | Naphtalene derivatives and their pharmaceutical use | ELI LILLY AND COMPANY | 2003-04-17 | — | — | US | disclosed |
| EP-1272469-A1 | NAPHTHALENE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2003-01-08 | — | — | EP | disclosed |
| EP-1138328-A1 | Naphthalene derivatives as CNS drugs | ELI LILLY AND COMPANY LIMITED (GB) | 2001-10-04 | — | — | EP | disclosed |
| WO-2001072709-A1 | NAPHTALENE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ELI LILLY AND COMPANY (US) | 2001-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073725-A1 | Naphtalene derivatives and their pharmaceutical use | CHRNA6, ATP6V1B2, GRM6 | RIOK2 1819/4885MTNR1A 197/4885MTNR1B 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.