Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RHOA | P61586 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500585 | 0.84 | LGMN (0.61) | PDE3BPDE3AKDM4EHSD17B10HPGD | |
| SCHEMBL3864702 | 0.80 | HRH3 (0.53) | KDM4EHSD17B10USP2NPSR1GAA | |
| Hydrochloric Acid SCHEMBL3863650 | 0.79 | HRH3 (0.52) | KDM4EHSD17B10USP2NPSR1GAA | |
| SCHEMBL5799831 | 0.79 | NOTUM (0.55) | PDE3BPDE3AKDM4EHSD17B10USP2 | |
| SCHEMBL5800611 | 0.77 | NOTUM (0.55) | PDE3BPDE3AKDM4EHSD17B10USP2 | |
| SCHEMBL13683680 | 0.77 | HRH3 (0.60) | KDM4EHSD17B10USP2KMT2ATP53 | |
| SCHEMBL4891157 | 0.76 | KDM4E (0.56) | PDE3BPDE3AKDM4EHSD17B10USP2 | |
| SCHEMBL13683687 | 0.76 | MAPT (0.42) | PDE3BPDE3AKDM4EHSD17B10USP2 | |
| Hydrochloric Acid SCHEMBL3868535 | 0.76 | HRH3 (0.59) | KDM4EHSD17B10USP2KMT2ATP53 | |
| SCHEMBL6948711 | 0.76 | HTR3E (0.57) | KDM4EHSD17B10USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |