Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502486 | 0.84 | PDE3B (0.59) | ALDH1A1KMT2AMEN1KDM4EHPGD | |
| SCHEMBL21533588 | 0.80 | LGMN (0.69) | LGMNALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL23086805 | 0.80 | LGMN (0.62) | LGMNALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6505529 | 0.79 | MAPT (0.59) | LGMNALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL7016361 | 0.79 | LGMN (0.61) | LGMNALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL21180884 | 0.79 | MAPT (0.62) | LGMNALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL30035162 | 0.78 | SHMT2 (0.57) | LGMNALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL23602258 | 0.78 | SHMT2 (0.57) | LGMNALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL15850037 | 0.78 | MAPT (0.71) | LGMNALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL23086849 | 0.78 | LGMN (0.60) | LGMNALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |