Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18341916 | 0.76 | ALDH1A1 (0.36) | IDO1POLBALDH1A1FKBP5HRH3 | |
| SCHEMBL25861866 | 0.74 | ALDH1A1 (0.44) | IDO1ALDH1A1FKBP5HRH3TSHR | |
| SCHEMBL6237061 | 0.69 | KMT2A (0.33) | ALDH1A1FKBP5TSHR | |
| SCHEMBL10506714 | 0.69 | KDM4A (0.33) | IDO1SMN1; SMN2ALDH1A1FKBP5HRH4 | |
| Hydrochloric Acid SCHEMBL28274257 | 0.68 | HRH3 (0.33) | IDO1POLBALDH1A1FKBP5HRH3 | |
| SCHEMBL28071244 | 0.67 | CCNT1 (0.33) | IDO1PKM | |
| Fluoxidine SCHEMBL1369498 | 0.65 | — | — | |
| SCHEMBL28202370 | 0.64 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL1371006 | 0.63 | — | — | |
| SCHEMBL27820767 | 0.61 | IDO1 (0.51) | IDO1SMN1; SMN2POLBADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003216-A | E1 activating enzyme inhibitors | 千禧药品公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-106008512-B | E1 activating enzyme inhibitors | 千禧药品公司 | 2019-03-12 | — | — | CN | disclosed |
| CN-106008512-A | INHIBITORS OF E1 ACTIVATING ENZYMES | 千禧药品公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-101379061-B | E1 activating enzyme inhibitor | 千禧药品公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-103288835-A | Inhibitors of E1 activating enzyme | MILLENNIUM PHARM INC | 2013-09-11 | — | — | CN | disclosed |
| CN-101379061-A | E1 activating enzyme inhibitor | MILLENNIUM PHARM INC (US) | 2009-03-04 | — | — | CN | disclosed |
| WO-2005016878-A3 | METHODS FOR THE PREPARATION OF 5-FLUORO-PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 2005-06-02 | — | — | WO | disclosed |
| WO-2005016878-A3 | METHODS FOR THE PREPARATION OF 5-FLUORO-PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 2005-06-02 | — | — | WO | disclosed |
| WO-2005016878-A2 | METHODS FOR THE PREPARATION OF 5-FLUORO-PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005016878-A2 | METHODS FOR THE PREPARATION OF 5-FLUORO-PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005016878-A2 | METHODS FOR THE PREPARATION OF 5-FLUORO-PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |