Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.76 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.76 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086803 | 0.89 | PTGES (0.80) | PTGESALOX5PTGS1ALOX5APPTGS2 | |
| SCHEMBL18782717 | 0.88 | PTGES (0.78) | PTGESALOX5PTGS1ALOX5APPTGS2 | |
| SCHEMBL6505087 | 0.88 | PTGES (0.78) | PTGESALOX5PTGS1ALOX5APPTGS2 | |
| SCHEMBL13697422 | 0.87 | PTGES (0.85) | PTGESALOX5PTGS1ALOX5APPTGS2 | |
| SCHEMBL3984072 | 0.87 | PTGES (0.77) | PTGESALOX5PTGS1ALOX5APPTGS2 | |
| Licofelone SCHEMBL237833 | 0.86 | ALOX5 (1.00) | PTGESALOX5PTGS1ALOX5APPTGS2 | |
| SCHEMBL18782719 | 0.85 | PTGES (0.74) | PTGESALOX5PTGS1ALOX5APPTGS2 | |
| SCHEMBL18782759 | 0.85 | PTGES (0.74) | PTGESALOX5PTGS1ALOX5APPTGS2 | |
| SCHEMBL20415012 | 0.84 | PTGES (0.73) | PTGESALOX5PTGS1ALOX5APPTGS2 | |
| Licofelone SCHEMBL7738810 | 0.84 | PTGES (0.83) | PTGESALOX5PTGS1ALOX5APPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |