Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | PTGES | O14684 | 3/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495185 | 0.87 | ALOX5 (0.51) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6499123 | 0.86 | ALOX5 (0.50) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6503974 | 0.81 | ALOX5 (0.81) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL13844797 | 0.77 | PTGES (0.61) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6495841 | 0.76 | ALOX5 (0.74) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL8397926 | 0.76 | ALOX5 (0.45) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6496842 | 0.73 | ALOX5 (0.47) | ALOX5PTGS1PTGS2HTTATM | |
| SCHEMBL6496837 | 0.73 | ALOX5 (0.47) | ALOX5PTGS1PTGS2HTTATM | |
| SCHEMBL8394771 | 0.71 | ALDH1A1 (0.39) | ALOX5PTGS1PTGS2PTGESALOX5AP | |
| SCHEMBL6505066 | 0.71 | PTGES (0.44) | ALOX5PTGS1PTGS2PTGESALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |