Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6495930 | 0.92 | MEN1 (0.46) | POLBGAAKDM4ELPAR1MEN1 | |
| SCHEMBL6236094 | 0.77 | MEN1 (0.55) | POLBKDM4EMEN1KMT2ALMNA | |
| SCHEMBL6503419 | 0.75 | ALDH1A1 (0.42) | GAAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8981951 | 0.74 | ALDH1A1 (0.48) | GAALMNAPTPN1ALDH1A1NPSR1 | |
| SCHEMBL8981959 | 0.74 | ALDH1A1 (0.48) | GAALMNAPTPN1ALDH1A1NPSR1 | |
| SCHEMBL8981944 | 0.74 | ALDH1A1 (0.48) | GAALMNAPTPN1ALDH1A1NPSR1 | |
| SCHEMBL7681570 | 0.73 | PTPN1 (0.53) | KMT2APTPN1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL6505410 | 0.72 | PPARA (0.62) | GAAKDM4E | |
| SCHEMBL6496834 | 0.72 | GAA (0.54) | POLBGAAKDM4ELPAR1MEN1 | |
| SCHEMBL6504914 | 0.72 | PPARA (0.52) | POLBGAAKDM4ELPAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |