Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 6/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13844797 | 0.90 | PTGES (0.61) | PTGESALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL6495216 | 0.82 | PTGES (0.62) | PTGESALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL5555192 | 0.78 | PTGES (0.80) | PTGESALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL14413899 | 0.76 | PTGES (0.67) | PTGESALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL6505066 | 0.75 | PTGES (0.44) | PTGESALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL8397926 | 0.74 | ALOX5 (0.45) | PTGESALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL6505736 | 0.73 | ALOX5 (0.66) | PTGESALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL6503465 | 0.72 | PTGES (0.64) | PTGESALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL6505733 | 0.71 | PTGES (0.45) | PTGESALOX5ALOX5APPTGS1PTGS2 | |
| SCHEMBL6495185 | 0.71 | ALOX5 (0.51) | PTGESALOX5ALOX5APPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |