Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.66 |
| ▸ | PTGES | O14684 | 3/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496842 | 0.81 | ALOX5 (0.47) | ALOX5PTGS1PTGS2ALDH1A1 | |
| SCHEMBL6505733 | 0.80 | PTGES (0.45) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL13844797 | 0.80 | PTGES (0.61) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL6503283 | 0.69 | ALOX5 (0.49) | ALOX5PTGS1PTGS2 | |
| SCHEMBL14413899 | 0.66 | PTGES (0.67) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL8397926 | 0.66 | ALOX5 (0.45) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9535514 | 0.64 | ALOX5 (0.46) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9458992 | 0.64 | ALOX5 (0.86) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL6505366 | 0.64 | ALOX5 (0.66) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9535920 | 0.64 | ALOX5 (0.47) | ALOX5PTGS1PTGESALOX5APPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878738-B1 | Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2005-04-12 | — | — | US | disclosed |