Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503897 | 1.00 | PABPC1 (0.52) | PABPC1EIF4HP2RX7HSD11B1GAA | |
| SCHEMBL6334534 | 0.89 | HSD11B1 (0.51) | PABPC1EIF4HP2RX7HSD11B1GAA | |
| SCHEMBL6334538 | 0.89 | HSD11B1 (0.51) | PABPC1EIF4HP2RX7HSD11B1GAA | |
| SCHEMBL6344429 | 0.88 | P2RX7 (0.48) | PABPC1EIF4HP2RX7HSD11B1GAA | |
| SCHEMBL6344433 | 0.88 | P2RX7 (0.48) | PABPC1EIF4HP2RX7HSD11B1GAA | |
| SCHEMBL6334639 | 0.84 | HSD11B1 (0.48) | P2RX7HSD11B1GAALMNAALDH1A1 | |
| SCHEMBL6334636 | 0.84 | HSD11B1 (0.48) | P2RX7HSD11B1GAALMNAALDH1A1 | |
| SCHEMBL6334700 | 0.84 | HSD11B1 (0.48) | P2RX7HSD11B1GAALMNAALDH1A1 | |
| SCHEMBL6334719 | 0.83 | HSD11B1 (0.49) | P2RX7HSD11B1GAALMNAALDH1A1 | |
| SCHEMBL6334725 | 0.83 | HSD11B1 (0.49) | P2RX7HSD11B1GAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | ASTRAZENECA AB | 2005-12-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | CYP3A5, IL5, ABCC5 | PABPC1 3039/4885EIF4H 1296/4885P2RX7 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.