Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4829502 | 0.83 | PTGS2 (0.48) | SMN1; SMN2PTGS2CSF1RHSD17B10 | |
| SCHEMBL6504454 | 0.74 | KDM4E (0.50) | KDM4EALDH1A1HPGDPTGS2HSD17B10 | |
| SCHEMBL4831735 | 0.72 | PTGS1 (0.48) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL6504452 | 0.72 | CA12 (0.45) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL4829759 | 0.70 | HSD17B1 (0.44) | LMNAPTGS2ICMT | |
| SCHEMBL13955899 | 0.68 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDLMNAPOLB | |
| SCHEMBL5715568 | 0.67 | PTGS2 (0.69) | HPGDLMNAPOLBSMN1; SMN2PTGS2 | |
| SCHEMBL4829754 | 0.67 | PTGS1 (0.44) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL4829512 | 0.66 | TAAR1 (0.53) | SMN1; SMN2PTGS2 | |
| SCHEMBL4832008 | 0.66 | TDP1 (0.48) | ALDH1A1LMNAMAPTSMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014534-A1 | ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2005-02-17 | — | — | WO | disclosed |