Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | FLT1 | P17948 | 3/20 | 0.53 |
| ▸ | GOT1 | P17174 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HLA-A | P04439 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496240 | 0.83 | KDR (0.58) | KDRFLT1GOT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10338919 | 0.83 | GOT1 (0.61) | MAPTKDRFLT1GOT1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6502127 | 0.82 | KDR (0.57) | KDRFLT1GOT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3759288 | 0.80 | KDR (0.63) | MAPTKDRSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL3764417 | 0.74 | SHMT2 (0.60) | MAPTKDRFLT1POLBGAA | |
| Hydrochloric Acid SCHEMBL6608902 | 0.74 | KDR (0.74) | KDRFLT1CITEGFRHLA-A | |
| SCHEMBL2200375 | 0.74 | MAPT (0.50) | MAPTKDRFLT1EGFRCSF1R | |
| SCHEMBL28961841 | 0.73 | GOT1 (0.53) | MAPTGOT1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL28961875 | 0.73 | GOT1 (0.53) | MAPTGOT1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL28961838 | 0.73 | GOT1 (0.53) | MAPTGOT1SMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903101-B1 | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |
| EP-1208096-B1 | SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER AG (US) | 2004-04-28 | — | — | EP | disclosed |
| CN-1378543-A | Substituted pyridazines and fused pyridazines having angiogenesis inhibiting activity | BAYER AG (US) | 2002-11-06 | — | — | CN | disclosed |
| EP-1208096-A1 | SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | Bayer Corporation (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001010859-A1 | SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER CORPORATION (US) | 2001-02-15 | — | — | WO | disclosed |