Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.58 |
| ▸ | FLT1 | P17948 | 6/20 | 0.58 |
| ▸ | GOT1 | P17174 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | HLA-A | P04439 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | FRK | P42685 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.57 |
| ▸ | STK3 | Q13188 | 1/20 | 0.57 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.57 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.57 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6502127 | 0.98 | KDR (0.57) | KDRFLT1GOT1CITEGFR | |
| SCHEMBL10338919 | 0.89 | GOT1 (0.61) | KDRFLT1GOT1CITEGFR | |
| SCHEMBL6505060 | 0.83 | MAPT (0.57) | KDRFLT1GOT1CITEGFR | |
| SCHEMBL3759288 | 0.82 | KDR (0.63) | KDRSMN1; SMN2NPC1RAB9AENPP3 | |
| SCHEMBL4738808 | 0.81 | PDE5A (0.69) | KDRGOT1EGFRSMN1; SMN2NPC1 | |
| SCHEMBL7915165 | 0.80 | ALDH1A1 (0.72) | KDRFLT1CITEGFRHLA-A | |
| SCHEMBL7913416 | 0.77 | NPSR1 (0.73) | KDRSMN1; SMN2ENPP3PDE5AKDM4E | |
| SCHEMBL31359772 | 0.76 | MAPT (0.64) | KDRFLT1GOT1EGFRRET | |
| SCHEMBL3764417 | 0.76 | SHMT2 (0.60) | KDRFLT1EGFRPDGFRBKIT | |
| SCHEMBL6606282 | 0.75 | KDR (0.72) | KDRGOT1EGFRSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1251097-B | Phthalazines with angiogenesis inhibiting activity | NOVARTIS AG | 2011-10-19 | — | — | CN | disclosed |
| US-6903101-B1 | Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |
| EP-1208096-B1 | SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER AG (US) | 2004-04-28 | — | — | EP | disclosed |
| CN-1378543-A | Substituted pyridazines and fused pyridazines having angiogenesis inhibiting activity | BAYER AG (US) | 2002-11-06 | — | — | CN | disclosed |
| EP-1208096-A1 | SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | Bayer Corporation (US) | 2002-05-29 | — | — | EP | disclosed |
| WO-2001010859-A1 | SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER CORPORATION (US) | 2001-02-15 | — | — | WO | disclosed |
| CN-1251097-A | Phthalazines with angiogenesis inhibiting activity | NOVARTIS AG (CH) | 2000-04-19 | — | — | CN | disclosed |