Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | LGMN | Q99538 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7693635 | 0.82 | MAPT (0.56) | MAPTTP53KDM4EKMT2AMEN1 | |
| SCHEMBL5800979 | 0.82 | HTR3A (0.58) | KDM4EHTR3ANPSR1AKR1C3 | |
| SCHEMBL21180884 | 0.79 | MAPT (0.62) | MAPTKDM4ELGMNKMT2AMEN1 | |
| SCHEMBL6500585 | 0.79 | LGMN (0.61) | MAPTTP53KDM4ELGMNKMT2A | |
| SCHEMBL14470851 | 0.79 | MAPT (0.57) | MAPTKDM4ELGMNKMT2AMEN1 | |
| SCHEMBL5913512 | 0.79 | MAPT (0.67) | MAPTKDM4ELGMNKMT2AMEN1 | |
| SCHEMBL16648765 | 0.78 | MAPT (0.63) | MAPTTP53KDM4EKMT2AMEN1 | |
| SCHEMBL13918371 | 0.77 | MAPT (0.55) | MAPTKDM4ELGMNKMT2AMEN1 | |
| SCHEMBL4890947 | 0.77 | LGMN (0.52) | MAPTTP53KDM4ELGMNKMT2A | |
| SCHEMBL16397946 | 0.76 | LGMN (0.63) | MAPTKDM4ELGMNKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |