SCHEMBL6505735

SCHEMBL6505735

COC(=O)Cc1nc(-c2ccc(F)cc2)oc1C

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.55
MEN1 O00255 1/20 0.52
NPC1 O15118 1/20 0.52
KMT2A Q03164 1/20 0.52
PPARG P37231 6/20 0.51
PPARA Q07869 6/20 0.51
MAPT P10636 3/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
PPARD Q03181 1/20 0.49
RAB9A P51151 1/20 0.48
ATM Q13315 1/20 0.48
POLB P06746 2/20 0.47
ALDH1A1 P00352 2/20 0.47
MAPK1 P28482 1/20 0.47
HSD17B10 Q99714 1/20 0.46
TP53 P04637 1/20 0.46
GAA P10253 1/20 0.46
TSHR P16473 1/20 0.46
LMNA P02545 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL821081 0.89 KDM4E (0.57) KDM4EMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL7906307 0.88 KDM4E (0.56) KDM4EMEN1KMT2APPARGPPARA
SCHEMBL4893515 0.86 KDM4E (0.70) KDM4ENPC1PPARGPPARAMAPT
SCHEMBL6607518 0.86 LMNA (0.60) KDM4EMEN1KMT2AMAPTSMN1; SMN2
SCHEMBL10652783 0.86 HSD17B10 (0.61) KDM4EPPARGPPARAMAPTSMN1; SMN2
SCHEMBL5215068 0.86 TARBP2 (0.55) KDM4EMEN1KMT2APPARGPPARA
SCHEMBL2930640 0.86 KDM4E (0.74) KDM4EPPARGPPARAMAPTSMN1; SMN2
SCHEMBL6606155 0.86 PPARA (0.52) KDM4EPPARGPPARAMAPTPPARD
SCHEMBL7922595 0.85 KDM4E (0.56) KDM4EMEN1NPC1KMT2APPARG
SCHEMBL27656200 0.85 KDM4E (0.57) KDM4EMEN1KMT2APPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1810795-A Benzopyran compound and its prepn and use SHANGHAI INST OF MEDICAMENTS C (CN) 2006-08-02 CN disclosed
WO-2005040127-A1 NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME LG LIFE SCIENCES LTD. (KR) 2005-05-06 WO disclosed
EP-1102757-B1 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS GLAXO GROUP LTD (GB) 2004-04-14 EP disclosed
US-6498174-B1 AGONISTS TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; MODULATING BLOOD GLUCOSE AND LIPID LEVELS; REDUCING DYSLIPIDEMIA AND HYPERINSULINEMIA ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE OR METABOLIC SYNDROME SMITHKLINE BEECHAM CORPORATION 2002-12-24 US disclosed
US-6294580-B1 FOR THERAPY AND PROPHYLAXIS OF TYPE II OR NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERGLYCAEMIA, DYSLIPIDEMIA, TYPE II DIABETES, TYPE I DIABETES, HYPERTRIGLYCERIDEMIA, SYNDROME X, INSULIN RESISTANCE, HEART FAILURE GLAXO WELLCOME INC. 2001-09-25 US disclosed
EP-0888317-B1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LTD (GB) 2001-09-12 EP disclosed
EP-1102757-A1 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2001-05-30 EP disclosed
WO-2000008002-A1 SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2000-02-17 WO disclosed
EP-0888317-A1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LIMITED (GB) 1999-01-07 EP disclosed
WO-1997031907-A1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LIMITED (GB) 1997-09-04 WO disclosed