Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL821081 | 0.87 | KDM4E (0.57) | KDM4EHSD17B10ALDH1A1MAPTTSHR | |
| SCHEMBL2930640 | 0.87 | KDM4E (0.74) | KDM4EMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL7906307 | 0.86 | KDM4E (0.56) | KDM4EHSD17B10ALDH1A1MAPTGAA | |
| SCHEMBL4893515 | 0.85 | KDM4E (0.70) | KDM4EMAPTLMNAHPGDSMN1; SMN2 | |
| SCHEMBL6505735 | 0.85 | KDM4E (0.55) | KDM4EHSD17B10ALDH1A1MAPTGAA | |
| SCHEMBL6607518 | 0.85 | LMNA (0.60) | KDM4EHSD17B10ALDH1A1MAPTGAA | |
| SCHEMBL5215068 | 0.85 | TARBP2 (0.55) | KDM4EHSD17B10ALDH1A1MAPTGAA | |
| SCHEMBL10652783 | 0.85 | HSD17B10 (0.61) | KDM4EHSD17B10ALDH1A1MAPTTSHR | |
| SCHEMBL6606155 | 0.84 | PPARA (0.52) | KDM4EMAPTPPARGPPARAPPARD | |
| SCHEMBL6293021 | 0.83 | KDM4E (0.52) | KDM4EHSD17B10ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294580-B1 | FOR THERAPY AND PROPHYLAXIS OF TYPE II OR NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERGLYCAEMIA, DYSLIPIDEMIA, TYPE II DIABETES, TYPE I DIABETES, HYPERTRIGLYCERIDEMIA, SYNDROME X, INSULIN RESISTANCE, HEART FAILURE | GLAXO WELLCOME INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0888317-B1 | SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA | GLAXO GROUP LTD (GB) | 2001-09-12 | — | — | EP | disclosed |