Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL821081 | 0.90 | KDM4E (0.57) | KDM4EHSD17B10MAPTALDH1A1TSHR | |
| SCHEMBL6607518 | 0.88 | LMNA (0.60) | KDM4EHSD17B10MAPTALDH1A1GAA | |
| SCHEMBL5215068 | 0.88 | TARBP2 (0.55) | KDM4EHSD17B10PPARGPPARAMAPT | |
| SCHEMBL10652783 | 0.88 | HSD17B10 (0.61) | KDM4EHSD17B10PPARGPPARAMAPT | |
| SCHEMBL4893515 | 0.88 | KDM4E (0.70) | KDM4EPPARGPPARAMAPTLMNA | |
| SCHEMBL6505735 | 0.88 | KDM4E (0.55) | KDM4EHSD17B10PPARGPPARAMAPT | |
| SCHEMBL2930640 | 0.87 | KDM4E (0.74) | KDM4EPPARGPPARAMAPTLMNA | |
| SCHEMBL7922595 | 0.86 | KDM4E (0.56) | KDM4EHSD17B10PPARGPPARAMAPT | |
| SCHEMBL28757510 | 0.85 | KDM4E (0.52) | KDM4EHSD17B10PPARGPPARAMAPT | |
| SCHEMBL6293021 | 0.85 | KDM4E (0.52) | KDM4EHSD17B10PPARGPPARAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083888-A1 | MULTIBINDING AGENTS THAT MODULATE PPARgamma AND RXR RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063983-A9 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999063983-A1 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |