Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509849 | 0.84 | CNR1 (0.51) | CNR1AVPR2AVPR1AADORA2AADORA2B | |
| SCHEMBL6510956 | 0.81 | CNR1 (0.42) | CNR1AVPR2AVPR1ACRHR1CSNK1E | |
| SCHEMBL6517585 | 0.81 | CNR1 (0.43) | CNR1MEN1KMT2AAVPR2AVPR1A | |
| SCHEMBL6510280 | 0.80 | CNR1 (0.38) | CNR1CRHR1MAT2A | |
| SCHEMBL6509571 | 0.78 | PIK3CA (0.44) | CNR1AVPR1AADORA2AADORA2BADORA1 | |
| SCHEMBL6508430 | 0.77 | CNR1 (0.44) | CNR1AVPR2AVPR1AADORA2AADORA2B | |
| SCHEMBL6510167 | 0.77 | CNR1 (0.36) | CNR1 | |
| SCHEMBL6509280 | 0.77 | CNR1 (0.39) | CNR1MEN1KMT2AAVPR2AVPR1A | |
| SCHEMBL6509276 | 0.77 | CNR1 (0.39) | CNR1MEN1KMT2AAVPR2AVPR1A | |
| SCHEMBL6514331 | 0.76 | CNR1 (0.42) | CNR1AVPR2AVPR1AADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | claimed |
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | disclosed |