Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 6/20 | 0.35 |
| ▸ | METAP2 | P50579 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510956 | 0.91 | CNR1 (0.42) | CNR1METAP2CRHR1 | |
| SCHEMBL6509849 | 0.82 | CNR1 (0.51) | CNR1 | |
| SCHEMBL6509571 | 0.80 | PIK3CA (0.44) | CNR1PDE2AMAT2APTGESPDE10A | |
| SCHEMBL6506306 | 0.80 | CNR1 (0.39) | CNR1CRHR1MAT2A | |
| SCHEMBL6517585 | 0.80 | CNR1 (0.43) | CNR1 | |
| SCHEMBL6510167 | 0.79 | CNR1 (0.36) | CNR1METAP2 | |
| SCHEMBL6508430 | 0.76 | CNR1 (0.44) | CNR1CNR2 | |
| SCHEMBL6509280 | 0.75 | CNR1 (0.39) | CNR1 | |
| SCHEMBL6509276 | 0.75 | CNR1 (0.39) | CNR1 | |
| SCHEMBL6514331 | 0.75 | CNR1 (0.42) | CNR1SMN1; SMN2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | claimed |
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | disclosed |