Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 12/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | BRD2 | P25440 | 3/20 | 0.32 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | METAP2 | P50579 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509571 | 0.82 | PIK3CA (0.44) | CNR1CYP1A2CYP3A4CYP2C9EGFR | |
| SCHEMBL6510956 | 0.81 | CNR1 (0.42) | CNR1METAP2 | |
| SCHEMBL6509849 | 0.80 | CNR1 (0.51) | CNR1 | |
| SCHEMBL6510280 | 0.79 | CNR1 (0.38) | CNR1METAP2 | |
| SCHEMBL6506306 | 0.77 | CNR1 (0.39) | CNR1 | |
| SCHEMBL6517585 | 0.77 | CNR1 (0.43) | CNR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL6508430 | 0.73 | CNR1 (0.44) | CNR1 | |
| SCHEMBL6509276 | 0.73 | CNR1 (0.39) | CNR1USP2 | |
| SCHEMBL6509280 | 0.73 | CNR1 (0.39) | CNR1USP2 | |
| SCHEMBL6514331 | 0.72 | CNR1 (0.42) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | claimed |
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | disclosed |