Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.52 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506347 | 0.84 | IKBKB (0.61) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL6504891 | 0.83 | IKBKB (0.57) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL6506008 | 0.82 | IKBKB (0.56) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL6530168 | 0.81 | IKBKB (0.62) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL6507659 | 0.80 | IKBKB (0.53) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL6503091 | 0.80 | IKBKB (0.50) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL6505282 | 0.79 | MAPT (0.55) | IKBKBJAK2JAK3CHEK1MEN1 | |
| SCHEMBL1385889 | 0.76 | JAK2 (1.00) | IKBKBJAK2JAK3CHEK1MAP4K4 | |
| SCHEMBL6507728 | 0.75 | IKBKB (0.50) | IKBKBJAK2JAK3MEN1EIF2AK2 | |
| SCHEMBL6507070 | 0.74 | IKBKB (0.46) | IKBKBJAK2JAK3CHEK1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |