Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | XPO1 | O14980 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872153 | 0.75 | HTT (0.39) | PPARGXPO1HTTMAOBUSP2 | |
| SCHEMBL6506357 | 0.69 | KEAP1 (0.39) | PPARGHTTUSP2FAAHKMT2A | |
| SCHEMBL7043686 | 0.69 | NOTUM (0.33) | XPO1 | |
| SCHEMBL29236658 | 0.69 | AR (0.32) | XPO1 | |
| SCHEMBL19018008 | 0.64 | CTSK (0.36) | MAPTALDH1A1 | |
| SCHEMBL8287314 | 0.61 | TAAR1 (0.49) | HTTUSP2KMT2AMEN1RAB9A | |
| SCHEMBL30449773 | 0.60 | BACE1 (0.64) | HTTMAOBUSP2IGF1RMAPT | |
| SCHEMBL895250 | 0.60 | BACE1 (0.64) | HTTMAOBUSP2IGF1RMAPT | |
| SCHEMBL1787999 | 0.60 | NOTUM (0.35) | XPO1 | |
| SCHEMBL14862574 | 0.60 | TSHR (0.50) | HTTKMT2AMEN1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |