Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.55 |
| ▸ | PARP3 | Q9Y6F1 | 4/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466395 | 0.91 | PARP1 (0.50) | PARP1PARP2PARP3HRH3TBK1 | |
| SCHEMBL6500784 | 0.80 | HDAC1 (0.44) | HDAC1HTTKDM4E | |
| SCHEMBL6467604 | 0.79 | HPGD (0.46) | HTTSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL6497388 | 0.79 | KDM4E (0.53) | PARP1PARP2PARP3RAB9ANPC1 | |
| SCHEMBL6470172 | 0.78 | ITK (0.38) | PARP1PARP2PARP3HDAC1RAB9A | |
| SCHEMBL6498693 | 0.78 | KDM4E (0.46) | RAB9ANPC1HTTSMN1; SMN2KDM4E | |
| SCHEMBL6507198 | 0.78 | MAP4K4 (0.47) | RAB9ANPC1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL12800693 | 0.77 | IRAK4 (0.55) | — | |
| SCHEMBL6467418 | 0.77 | IRAK4 (0.45) | PARP1TBK1HDAC1RAB9ANPC1 | |
| SCHEMBL6504415 | 0.77 | KDM4E (0.50) | HDAC1RAB9ANPC1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | PARP1 1904/4885PARP2 1481/4885PARP3 1517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.