Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956867 | 0.81 | HTR1B (0.42) | ADRB2ADRB1ADRB3HTR1BMAPT | |
| SCHEMBL516150 | 0.73 | MAPT (0.44) | ADRB2ADRB1ADRB3HTR1BMAPT | |
| SCHEMBL4778014 | 0.71 | MAPT (0.40) | ADRB2ADRB1ADRB3HTR1BMAPT | |
| SCHEMBL15346262 | 0.70 | KDM4E (0.42) | ADRB2ADRB1ADRB3RAB9AL3MBTL1 | |
| SCHEMBL5325948 | 0.69 | MAPT (0.47) | HTR1BMAPTRAB9ALMNAL3MBTL1 | |
| SCHEMBL3720870 | 0.69 | MAPT (0.47) | HTR1BMAPTPOLBKMT2AMEN1 | |
| SCHEMBL20552998 | 0.67 | ADRB2 (0.45) | ADRB2ADRB1ADRB3LMNAKMT2A | |
| SCHEMBL15346433 | 0.67 | HTR1B (0.41) | ADRB2ADRB1ADRB3HTR1BMAPT | |
| SCHEMBL14271680 | 0.67 | MAPT (0.44) | HTR1BMAPTRAB9ALMNAL3MBTL1 | |
| SCHEMBL14290588 | 0.66 | KMT2A (0.50) | ADRB2ADRB1ADRB3HTR1BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005099699-A1 | COMBINATION OF (S)-AMLODIPINE AND A BETA-BLOCKER, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-10-27 | — | — | WO | disclosed |