Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516150 | 0.81 | MAPT (0.44) | MAPTHTR1BPOLBTRPA1ATM | |
| SCHEMBL3720870 | 0.77 | MAPT (0.47) | MAPTHTR1BPOLBTRPA1ATM | |
| SCHEMBL5325948 | 0.77 | MAPT (0.47) | MAPTHTR1BPOLBTRPA1ATM | |
| SCHEMBL3956867 | 0.76 | HTR1B (0.42) | MAPTHTR1BPOLBTRPA1ATM | |
| SCHEMBL14271680 | 0.73 | MAPT (0.44) | MAPTHTR1BPOLBTRPA1ATM | |
| Bromide SCHEMBL25206394 | 0.72 | MAPT (0.43) | MAPTHTR1BPOLBTRPA1ATM | |
| SCHEMBL12476734 | 0.71 | TRPA1 (0.61) | MAPTHTR1BPOLBTRPA1ATM | |
| SCHEMBL16234636 | 0.71 | TSHR (0.46) | MAPTPOLBKMT2AKDM4ELMNA | |
| SCHEMBL6506744 | 0.71 | ADRB2 (0.40) | MAPTHTR1BPOLBKMT2AKDM4E | |
| SCHEMBL16955002 | 0.71 | MAPT (0.46) | MAPTHTR1BPOLBTRPA1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008016811-A2 | AMINOPIPERIDINES AND REALTED COMPOUNDS | NEUROGEN CORPORATION (US) | 2008-02-07 | — | — | WO | disclosed |