Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 13/20 | 0.58 |
| ▸ | TACR3 | P29371 | 9/20 | 0.58 |
| ▸ | TACR2 | P21452 | 7/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203642 | 0.88 | TRPV4 (0.73) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6507791 | 0.87 | TACR3 (0.62) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6528864 | 0.86 | TRPV4 (0.55) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6853291 | 0.81 | TRPV4 (0.55) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5945408 | 0.81 | TRPV4 (0.55) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5202474 | 0.79 | TACR3 (0.59) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL2373330 | 0.78 | TRPV4 (0.72) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| Hydrochloric Acid SCHEMBL5733490 | 0.77 | TRPV4 (0.71) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6533888 | 0.77 | TRPV4 (0.54) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL4237458 | 0.76 | TACR3 (0.88) | TRPV4TACR3TACR2OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000845-A2 | BICYCLIC DERIVATIVES AS NK-1 AND NK-2 ANTAGONISTS | NIKEM RESEARCH S.R.L. (IT) | 2005-01-06 | — | — | WO | disclosed |