Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 15/20 | 0.55 |
| ▸ | TACR3 | P29371 | 6/20 | 0.55 |
| ▸ | TACR2 | P21452 | 5/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6533888 | 0.91 | TRPV4 (0.54) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6506812 | 0.86 | TRPV4 (0.58) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5203642 | 0.85 | TRPV4 (0.73) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5202474 | 0.82 | TACR3 (0.59) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL5945408 | 0.81 | TRPV4 (0.55) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL6868096 | 0.79 | TRPV4 (0.62) | TRPV4TACR3TACR2KCNH2CACNA1C | |
| SCHEMBL6853291 | 0.79 | TRPV4 (0.55) | TRPV4TACR3TACR2OPRM1KCNH2 | |
| SCHEMBL2372637 | 0.79 | TRPV4 (0.75) | TRPV4TACR3TACR2KCNH2CACNA1C | |
| SCHEMBL6506224 | 0.78 | TACR3 (0.38) | TACR3TACR2KCNH2OPRK1 | |
| SCHEMBL6393346 | 0.76 | TRPV4 (0.58) | TRPV4TACR3TACR2OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000845-A2 | BICYCLIC DERIVATIVES AS NK-1 AND NK-2 ANTAGONISTS | NIKEM RESEARCH S.R.L. (IT) | 2005-01-06 | — | — | WO | disclosed |