Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 5/20 | 0.70 |
| ▸ | CRHR2 | Q13324 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510020 | 0.90 | CRHBP (0.56) | CRHBPCRHR2MEN1KMT2AMAPT | |
| SCHEMBL6508975 | 0.86 | MEN1 (0.53) | CRHBPCRHR2MEN1KMT2AMAPT | |
| SCHEMBL6513445 | 0.84 | CRHBP (0.65) | CRHBPCRHR2MEN1KMT2AMAPT | |
| SCHEMBL6513368 | 0.82 | CRHBP (1.00) | CRHBPCRHR2MEN1KMT2AMAPT | |
| SCHEMBL6509097 | 0.79 | MAPK1 (0.54) | CRHBPCRHR2MEN1KMT2AMAPT | |
| SCHEMBL6511099 | 0.75 | CRHBP (0.57) | CRHBPCRHR2MEN1KMT2AMAPT | |
| SCHEMBL10498926 | 0.73 | CRHBP (0.83) | CRHBPCRHR2MEN1KMT2AMAPT | |
| SCHEMBL6510821 | 0.72 | CRHBP (0.80) | CRHBPCRHR2MEN1KMT2AMAPT | |
| SCHEMBL5923420 | 0.70 | SMN1; SMN2 (0.52) | CRHBPCRHR2MEN1KMT2AMAPT | |
| SCHEMBL6509580 | 0.70 | SMN1; SMN2 (0.55) | CRHBPCRHR2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |