Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CRHBP | P24387 | 5/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509984 | 0.90 | MAPK1 (0.54) | SMN1; SMN2LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL6513445 | 0.85 | CRHBP (0.65) | SMN1; SMN2LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL6508975 | 0.85 | MEN1 (0.53) | SMN1; SMN2LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL6509097 | 0.78 | MAPK1 (0.54) | SMN1; SMN2LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL4979491 | 0.76 | SIGMAR1 (0.66) | SMN1; SMN2LMNAKMT2AADRA2A | |
| SCHEMBL6512924 | 0.75 | CRHBP (0.68) | SMN1; SMN2LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL6510712 | 0.73 | CRHBP (0.60) | SMN1; SMN2LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL5922903 | 0.71 | KMT2A (0.72) | SMN1; SMN2LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL6506989 | 0.70 | CRHBP (0.70) | SMN1; SMN2LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL6512853 | 0.67 | SIGMAR1 (0.72) | SMN1; SMN2LMNAMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |