Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507430 | 1.00 | MAPT (0.66) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL18112346 | 0.88 | SMN1; SMN2 (0.54) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL18112345 | 0.88 | SMN1; SMN2 (0.54) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL6496803 | 0.85 | MAPT (0.74) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL6496805 | 0.85 | MAPT (0.74) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL6168977 | 0.82 | ALDH1A1 (0.57) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL6168986 | 0.82 | ALDH1A1 (0.57) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL29913976 | 0.82 | APP (0.66) | MAPTALDH1A1LMNAMAPK1HPGD | |
| SCHEMBL358099 | 0.81 | TUBB4A (0.63) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL8237371 | 0.81 | TTR (0.52) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |