Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 13/20 | 0.78 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.78 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.78 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.78 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.78 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.78 |
| ▸ | GPR183 | P32249 | 1/20 | 0.78 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.78 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.74 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.73 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.64 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fingolimod SCHEMBL15515724 | 0.96 | S1PR1 (0.85) | S1PR1S1PR3S1PR4TNNC1S1PR5 | |
| SCHEMBL5399738 | 0.93 | S1PR1 (0.91) | S1PR1S1PR3S1PR4TNNC1S1PR5 | |
| SCHEMBL6529926 | 0.93 | S1PR1 (0.91) | S1PR1S1PR3S1PR4TNNC1S1PR5 | |
| SCHEMBL6528485 | 0.93 | S1PR1 (0.91) | S1PR1S1PR3S1PR4TNNC1S1PR5 | |
| Hydrochloric Acid SCHEMBL6240646 | 0.92 | S1PR1 (0.91) | S1PR1S1PR3S1PR4TNNC1S1PR5 | |
| SCHEMBL6502901 | 0.92 | S1PR1 (0.88) | S1PR1S1PR3S1PR4TNNC1S1PR5 | |
| Hydrochloric Acid SCHEMBL6529334 | 0.90 | S1PR1 (0.88) | S1PR1S1PR3S1PR4TNNC1S1PR5 | |
| SCHEMBL3394797 | 0.89 | S1PR1 (1.00) | S1PR1S1PR3S1PR4TNNC1S1PR5 | |
| SCHEMBL18904548 | 0.89 | S1PR1 (1.00) | S1PR1S1PR3S1PR4TNNC1S1PR5 | |
| Fingolimod SCHEMBL7445 | 0.89 | S1PR1 (1.00) | S1PR1S1PR3S1PR4TNNC1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014525-A2 | BI-ARYL COMPOUND HAVING IMMUNOSUPPRESSIVE ACTIVITY | MITSUBISHI PHARMA CORPORATION (JP) | 2005-02-17 | — | — | WO | disclosed |
| WO-2005009974-A1 | IMIDAZOLE COMPOUNDS AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2005-02-03 | — | — | WO | disclosed |