Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504845 | 0.92 | ITK (0.46) | ITKIRAK4HDAC2LMNASMN1; SMN2 | |
| SCHEMBL6467349 | 0.92 | ITK (0.46) | ITKIRAK4LMNASMN1; SMN2SCN9A | |
| SCHEMBL6470464 | 0.90 | KDM4E (0.46) | ITKIRAK4LMNASMN1; SMN2SCN9A | |
| SCHEMBL6469989 | 0.89 | IRAK4 (0.56) | ITKIRAK4LMNASMN1; SMN2SCN9A | |
| SCHEMBL6467744 | 0.88 | SMN1; SMN2 (0.48) | ITKLMNASMN1; SMN2SCN9AKDM4E | |
| SCHEMBL6505904 | 0.86 | ITK (0.48) | ITKIRAK4HDAC2LMNASMN1; SMN2 | |
| SCHEMBL6503522 | 0.85 | ITK (0.48) | ITKIRAK4LMNASMN1; SMN2SCN9A | |
| SCHEMBL6508710 | 0.85 | IKBKB (0.47) | ITKIRAK4LMNASMN1; SMN2SCN9A | |
| SCHEMBL6499349 | 0.85 | SCN9A (0.51) | ITKIRAK4LMNASMN1; SMN2SCN9A | |
| SCHEMBL6500349 | 0.85 | SMN1; SMN2 (0.47) | ITKIRAK4HDAC2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | ITK 4236/4885IRAK4 27/4885HDAC2 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.