SCHEMBL6507731

SCHEMBL6507731

COC(=O)[C@@H](CC(C)C)Nc1nc(Cc2ccc(OC)cc2)cc(Nc2cccc(F)c2)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MAPT P10636 4/20 0.39
LMNA P02545 2/20 0.39
CTSK P43235 2/20 0.39
HPGD P15428 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
POLB P06746 1/20 0.38
SLC2A1 P11166 1/20 0.38
TAS1R3 Q7RTX0 3/20 0.38
TAS1R1 Q7RTX1 3/20 0.38
NPR3 P17342 1/20 0.38
CNR2 P34972 2/20 0.37
CNR1 P21554 1/20 0.37
GALR2 O43603 1/20 0.37
TP53 P04637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6507727 1.00 CYP2C9 (0.43) CYP2C9CYP2C19ALDH1A1CYP1A2CYP2D6
SCHEMBL6515009 0.93 ALDH1A1 (0.43) CYP2C9CYP2C19ALDH1A1CYP1A2CYP2D6
SCHEMBL6515005 0.93 ALDH1A1 (0.43) CYP2C9CYP2C19ALDH1A1CYP1A2CYP2D6
SCHEMBL6528805 0.87 CYP2C9 (0.44) CYP2C9CYP2C19ALDH1A1CYP1A2CYP2D6
SCHEMBL8298689 0.87 CYP2C9 (0.44) CYP2C9CYP2C19ALDH1A1CYP1A2CYP2D6
SCHEMBL6512117 0.85 CTSK (0.38) CYP2C9CYP2C19ALDH1A1CYP1A2CYP2D6
SCHEMBL6512111 0.85 CTSK (0.38) CYP2C9CYP2C19ALDH1A1CYP1A2CYP2D6
SCHEMBL6510872 0.85 NPR3 (0.44) CYP2C9CYP2C19MAPTLMNASMN1; SMN2
SCHEMBL6510875 0.85 NPR3 (0.44) CYP2C9CYP2C19MAPTLMNASMN1; SMN2
SCHEMBL6530423 0.82 ALDH1A1 (0.47) CYP2C9CYP2C19ALDH1A1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005003103-A2 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES ASTRAZENECA AB (SE) 2005-01-13 WO claimed
WO-2005003103-A2 2, 4, 6-TRI-SUBSTITUTED 6-MEMBERED HETEROCYCLES AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES ASTRAZENECA AB (SE) 2005-01-13 WO disclosed