Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8278308 | 0.90 | HTT (0.48) | HTTNPC1RAB9AALDH2KMT2A | |
| SCHEMBL13676296 | 0.86 | L3MBTL1 (0.53) | HTTNPC1RAB9AALDH2KMT2A | |
| SCHEMBL8290091 | 0.84 | HTT (0.43) | HTTNPC1RAB9AALDH2KMT2A | |
| SCHEMBL4423700 | 0.81 | HTT (0.45) | HTTNPC1RAB9AALDH2KMT2A | |
| SCHEMBL8289194 | 0.80 | LDHA (0.49) | HTTNPC1RAB9AALDH2KMT2A | |
| SCHEMBL16197778 | 0.80 | HTT (0.48) | HTTNPC1RAB9AKMT2AL3MBTL1 | |
| SCHEMBL13676308 | 0.79 | ACHE (0.44) | HTTNPC1RAB9AALDH2KMT2A | |
| SCHEMBL8287895 | 0.79 | L3MBTL1 (0.47) | HTTNPC1RAB9AALDH2KMT2A | |
| SCHEMBL4172031 | 0.79 | ACHE (0.46) | HTTNPC1ALDH2L3MBTL1GAA | |
| SCHEMBL8278360 | 0.77 | HIF1A (0.48) | HTTALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058885-A2 | PIPERIDINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-30 | — | — | WO | disclosed |
| WO-2005058885-A2 | PIPERIDINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORTER INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-30 | — | — | WO | disclosed |