Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10535054 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A | |
| SCHEMBL23130401 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A | |
| SCHEMBL7454074 | 0.82 | KMT2A (0.41) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A | |
| SCHEMBL411806 | 0.81 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A | |
| SCHEMBL6925024 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A | |
| SCHEMBL2783538 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A | |
| SCHEMBL6925027 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A | |
| SCHEMBL6925032 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A | |
| SCHEMBL13858310 | 0.79 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A | |
| SCHEMBL7706526 | 0.78 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1ALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6958341-B2 | Pyrazolopyrimidines as CRF antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-10-25 | — | — | US | disclosed |
| US-20030139426-A1 | Pyrazolopyrimidines as CRF antagonists | WILDE RICHARD G (US) | 2003-07-24 | — | — | US | disclosed |
| WO-2000059908-A2 | PYRAZOLOPYRIMIDINES AS CRF ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139426-A1 | Pyrazolopyrimidines as CRF antagonists | CRHR1, CRHR2, CRH | SMN1; SMN2 1074/4885L3MBTL1 3853/4885ALDH1A1 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.