Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500080 | 0.91 | CCR8 (0.50) | GAABCHEKDM4ELMNAAPP | |
| SCHEMBL6501980 | 0.90 | GAA (0.69) | GAABCHEPOLBKDM4ELMNA | |
| SCHEMBL6498806 | 0.88 | ACHE (0.50) | BCHEKDM4EAPPACHE | |
| SCHEMBL6496812 | 0.86 | BCHE (0.55) | BCHEPOLBLMNAAPPACHE | |
| SCHEMBL6499418 | 0.85 | APP (0.46) | BCHEAPPACHE | |
| SCHEMBL6503409 | 0.84 | MCHR1 (0.47) | BCHEAPPACHE | |
| SCHEMBL6500610 | 0.84 | GAA (0.59) | GAABCHEKDM4ELMNAHPGD | |
| SCHEMBL6498983 | 0.84 | APP (0.49) | POLBAPPACHE | |
| SCHEMBL6506745 | 0.84 | ATM (0.48) | POLBKDM4EAPPACHEHPGD | |
| SCHEMBL6505243 | 0.83 | ACHE (0.51) | GAAAPPACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| WO-2003037271-A2 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS,INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | GAA 2177/4885BCHE 945/4885POLB 3458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.