Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.42 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6498801 | 0.93 | IRAK4 (0.45) | RAB9AMEN1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL6504994 | 0.86 | IRAK4 (0.48) | RAB9ANPC1SMN1; SMN2SCN9AMAPT | |
| SCHEMBL6500705 | 0.85 | MEN1 (0.44) | RAB9AMEN1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL6504845 | 0.84 | ITK (0.46) | RAB9ANPC1SMN1; SMN2SCN9AMAPT | |
| SCHEMBL6468716 | 0.84 | BACE1 (0.44) | RAB9AMEN1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL6468696 | 0.83 | TP53 (0.43) | SMN1; SMN2SCN9AMAPTKDM4ELMNA | |
| SCHEMBL6501255 | 0.82 | ITK (0.45) | RAB9AMEN1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL6499548 | 0.82 | ITK (0.45) | RAB9AMEN1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL6499939 | 0.82 | SCN9A (0.41) | SCN9AITKKCNH2IRAK4 | |
| SCHEMBL6466393 | 0.81 | KDM4E (0.38) | RAB9ANPC1SMN1; SMN2JAK1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | PHARMACIA AND UPJOHN COMPANY LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197338-A1 | Substituted pyrazole urea compounds for the treatment of inflammation | IL4, ARG2, CASP4 | RAB9A 2534/4885MEN1 4599/4885NPC1 3546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.