Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TACR3 | P29371 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509749 | 0.86 | DHODH (0.94) | DHODHTSHRPDE10A | |
| SCHEMBL6506852 | 0.85 | DHODH (0.56) | DHODHTSHRPDE10ASMN1; SMN2TACR3 | |
| SCHEMBL2372674 | 0.83 | PDE10A (0.73) | DHODHTSHRPDE10ASMN1; SMN2TACR3 | |
| SCHEMBL9954367 | 0.76 | DHODH (0.63) | DHODHTSHRPDE10AMEN1KMT2A | |
| SCHEMBL2459661 | 0.75 | DHODH (0.72) | DHODH | |
| SCHEMBL2124987 | 0.75 | DHODH (0.62) | DHODHTSHRPDE10AMEN1KMT2A | |
| SCHEMBL17594221 | 0.74 | DHODH (0.71) | DHODHTSHRPDE10A | |
| SCHEMBL14553152 | 0.74 | DHODH (0.95) | DHODHPDE10A | |
| SCHEMBL30690105 | 0.74 | PLA2G2A (0.58) | DHODHTSHRPDE10ATACR3MEN1 | |
| SCHEMBL5945348 | 0.73 | DHODH (0.63) | DHODHTSHRPDE10ASMN1; SMN2TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000845-A2 | BICYCLIC DERIVATIVES AS NK-1 AND NK-2 ANTAGONISTS | NIKEM RESEARCH S.R.L. (IT) | 2005-01-06 | — | — | WO | disclosed |