Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509265 | 0.85 | DHODH (0.72) | DHODHSMN1; SMN2GABRA1GABRG2GABRB3 | |
| SCHEMBL2372595 | 0.84 | SMN1; SMN2 (0.54) | DHODHSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL6506812 | 0.76 | TRPV4 (0.58) | TACR3 | |
| SCHEMBL9953191 | 0.75 | DHODH (0.47) | DHODHSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL27729454 | 0.74 | LMNA (0.53) | DHODHSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL6509749 | 0.74 | DHODH (0.94) | DHODHTSHRPDE10A | |
| SCHEMBL2373281 | 0.74 | KDM4E (0.55) | DHODHSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL4668037 | 0.74 | TACR3 (0.53) | DHODHSMN1; SMN2KMT2AMEN1TACR3 | |
| SCHEMBL4875432 | 0.72 | KDM4E (0.49) | SMN1; SMN2KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL5908880 | 0.72 | KDM4E (0.48) | DHODHSMN1; SMN2KMT2AMEN1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000845-A2 | BICYCLIC DERIVATIVES AS NK-1 AND NK-2 ANTAGONISTS | NIKEM RESEARCH S.R.L. (IT) | 2005-01-06 | — | — | WO | disclosed |