Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28847477 | 0.78 | ALDH1A1 (0.43) | NPSR1ALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL11076422 | 0.76 | NPSR1 (0.50) | NPSR1ALDH1A1MAPTKDM4ECYP1A2 | |
| SCHEMBL13343478 | 0.73 | HTT (0.42) | NPSR1MAPTALOX15HTTCA2 | |
| SCHEMBL224889 | 0.73 | ALDH1A1 (0.52) | NPSR1ALDH1A1MAPTKDM4ECYP1A2 | |
| SCHEMBL29713830 | 0.73 | ALDH1A1 (0.52) | NPSR1ALDH1A1MAPTKDM4ECYP1A2 | |
| SCHEMBL1478491 | 0.72 | TAAR1 (0.52) | ALDH1A1KDM4EHTTCA2ICMT | |
| SCHEMBL30570712 | 0.72 | TAAR1 (0.52) | ALDH1A1KDM4EHTTCA2ICMT | |
| SCHEMBL2702114 | 0.72 | ICMT (0.45) | HTTCA2ICMTKMT2A | |
| SCHEMBL30604467 | 0.72 | MEN1 (0.40) | NPSR1ALDH1A1KDM4EHTTICMT | |
| SCHEMBL30595358 | 0.72 | SHBG (0.54) | NPSR1ALDH1A1MAPTKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005004808-A2 | TETRACYCLIC COMPOUNDS AS c-MET INHIBITORS | SUGEN, INC. (US) | 2005-01-20 | — | — | WO | disclosed |