Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 2/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6509978 | 0.81 | NOS3 (0.48) | KMT2ALMNASMN1; SMN2L3MBTL1CRHBP | |
| SCHEMBL6510782 | 0.79 | NOS3 (0.45) | KMT2ALMNAHTTSMN1; SMN2AHR | |
| SCHEMBL5923477 | 0.76 | TEK (0.44) | KMT2ALMNAHTTSMN1; SMN2AHR | |
| SCHEMBL4113783 | 0.71 | GRIN2D (0.56) | KMT2ALMNAHTTSMN1; SMN2AHR | |
| SCHEMBL6509226 | 0.70 | NOS3 (0.46) | LMNASMN1; SMN2L3MBTL1HPGDTSHR | |
| SCHEMBL9325871 | 0.69 | PDE4A (0.59) | KMT2ALMNACYP1A2HPGDMAPT | |
| SCHEMBL6179442 | 0.67 | L3MBTL1 (0.47) | KMT2ALMNAL3MBTL1MEN1MAPT | |
| SCHEMBL6515597 | 0.67 | NOS3 (0.45) | KMT2ALMNAHTTSMN1; SMN2AHR | |
| SCHEMBL1265515 | 0.67 | CYP3A4 (0.45) | KMT2ALMNACYP1A2HPGDMAPT | |
| SCHEMBL5923158 | 0.66 | HDAC3 (0.42) | KMT2ALMNAHTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |