SCHEMBL6509908

SCHEMBL6509908

Brc1ccc(-c2ncc(CNCCOc3ccccc3)cn2)s1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.54
DRD4 P21917 6/20 0.54
ROCK1 Q13464 1/20 0.44
DRD2 P14416 3/20 0.43
DRD3 P35462 3/20 0.43
GAA P10253 1/20 0.43
ADRA1D P25100 2/20 0.42
ADRA1A P35348 2/20 0.42
ADRA1B P35368 2/20 0.42
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
PPARG P37231 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6510559 0.83 HDAC1 (0.79) HDAC1HDAC3HDAC4HDAC7HDAC2
SCHEMBL8293231 0.80 HDAC1 (0.62) HDAC1DRD4GAAHDAC3HDAC4
SCHEMBL6513490 0.76 TSHR (0.48) HDAC1KDM4E
SCHEMBL6508504 0.75 DRD4 (0.64) HDAC1DRD4ROCK1DRD2DRD3
SCHEMBL8740486 0.72 DRD4 (1.00) HDAC1DRD4DRD2DRD3GAA
SCHEMBL6832002 0.71 DRD4 (0.77) HDAC1DRD4ROCK1DRD2DRD3
SCHEMBL6507596 0.71 HDAC1 (1.00) HDAC1
SCHEMBL6508309 0.70 HDAC1 (0.84) HDAC1DRD4
SCHEMBL6511346 0.69 HDAC1 (0.38) HDAC1HDAC3HDAC2PPARGKDM4E
SCHEMBL9080658 0.67 DRD4 (0.80) HDAC1DRD4DRD2DRD3GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005014588-A1 SUBSTITUTED THIENYL-HYDROXAMIC ACIDS HAVING HISTONE DEACETYLASE ACTIVITY ARGENTA DISCOVERY LIMITED (GB) 2005-02-17 WO disclosed
WO-2005014588-A1 SUBSTITUTED THIENYL-HYDROXAMIC ACIDS HAVING HISTONE DEACETYLASE ACTIVITY ARGENTA DISCOVERY LIMITED (GB) 2005-02-17 WO disclosed