Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | GBA1 | P04062 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510602 | 0.89 | MAPK1 (0.63) | MAPK1GBA1KMT2ARAB9ALMNA | |
| SCHEMBL4981988 | 0.81 | MAPK1 (0.69) | MAPK1KMT2ARAB9ALMNAMEN1 | |
| SCHEMBL6513286 | 0.80 | MAPK1 (0.62) | MAPK1KMT2ARAB9ALMNAMEN1 | |
| SCHEMBL6510506 | 0.79 | MAPK1 (0.56) | MAPK1KMT2ARAB9ALMNAMEN1 | |
| SCHEMBL5923022 | 0.78 | GBA1 (0.59) | MAPK1GBA1KMT2ARAB9ALMNA | |
| SCHEMBL6508660 | 0.76 | MAPK1 (0.52) | MAPK1KMT2ARAB9ALMNAMEN1 | |
| SCHEMBL9392429 | 0.76 | SIGMAR1 (0.56) | MAPK1KMT2ARAB9APOLBSIGMAR1 | |
| SCHEMBL7507926 | 0.76 | MAOB (0.57) | MAPK1 | |
| SCHEMBL4985874 | 0.75 | MAPK1 (0.64) | MAPK1KMT2ARAB9ALMNAMEN1 | |
| SCHEMBL4984270 | 0.75 | MAPK1 (0.67) | MAPK1KMT2ARAB9ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |