Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6513739 | 0.85 | SMN1; SMN2 (0.42) | LMNARAB9AMEN1POLBKMT2A | |
| SCHEMBL6510506 | 0.83 | MAPK1 (0.56) | MAPK1LMNARAB9AMEN1POLB | |
| SCHEMBL6509392 | 0.82 | MAPT (0.43) | LMNARAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL5923574 | 0.82 | MAPK1 (0.46) | MAPK1LMNARAB9AMEN1KMT2A | |
| SCHEMBL6513286 | 0.80 | MAPK1 (0.62) | MAPK1LMNARAB9AMEN1POLB | |
| SCHEMBL6511304 | 0.77 | MAPT (0.45) | LMNARAB9AMEN1POLBKMT2A | |
| SCHEMBL6510249 | 0.76 | MAPK1 (0.62) | MAPK1LMNARAB9AMEN1POLB | |
| SCHEMBL4100977 | 0.75 | SIGMAR1 (0.55) | LMNAKMT2ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL4981988 | 0.75 | MAPK1 (0.69) | MAPK1LMNARAB9AMEN1POLB | |
| SCHEMBL6510602 | 0.75 | MAPK1 (0.63) | MAPK1LMNARAB9AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005095345-A2 | HETEROARYL GUANIDINES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |