Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.44 |
| ▸ | IKBKB | O14920 | 8/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6508194 | 0.86 | IKBKB (0.46) | CHEK1IKBKBJAK2MEN1KMT2A | |
| SCHEMBL6511724 | 0.80 | MAPT (0.51) | CHEK1IKBKBJAK2MEN1KMT2A | |
| SCHEMBL6507704 | 0.77 | CHEK1 (0.49) | CHEK1IKBKBJAK2MEN1KMT2A | |
| SCHEMBL6505282 | 0.76 | MAPT (0.55) | CHEK1IKBKBJAK2MEN1KMT2A | |
| SCHEMBL6509621 | 0.74 | SMN1; SMN2 (0.65) | CHEK1IKBKBMEN1KMT2AMAPT | |
| SCHEMBL6505484 | 0.73 | CHEK1 (0.55) | CHEK1IKBKBJAK2MEN1KMT2A | |
| SCHEMBL1563630 | 0.73 | CHEK1 (0.45) | CHEK1IKBKBJAK2MEN1KMT2A | |
| SCHEMBL6504891 | 0.72 | IKBKB (0.57) | CHEK1IKBKBJAK2MEN1KMT2A | |
| SCHEMBL6514964 | 0.71 | CHEK1 (0.57) | CHEK1IKBKBMEN1KMT2ATDP1 | |
| SCHEMBL6507070 | 0.71 | IKBKB (0.46) | CHEK1IKBKBJAK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |