Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504891 | 0.82 | IKBKB (0.57) | KDM4EKMT2ACHEK1IKBKBJAK2 | |
| SCHEMBL6506008 | 0.81 | IKBKB (0.56) | KCNK3KCNK9KMT2ACHEK1IKBKB | |
| SCHEMBL7003324 | 0.80 | IKBKB (0.64) | MAPTKDM4ECHEK1IKBKBJAK2 | |
| SCHEMBL6507659 | 0.79 | IKBKB (0.53) | MAPTKDM4EKMT2ACHEK1IKBKB | |
| SCHEMBL6508136 | 0.79 | IKBKB (0.60) | MAPTKMT2ATP53CHEK1IKBKB | |
| SCHEMBL6503091 | 0.79 | IKBKB (0.50) | KCNK3KCNK9KMT2ACHEK1IKBKB | |
| SCHEMBL6509621 | 0.79 | SMN1; SMN2 (0.65) | MAPTKDM4EKMT2ATP53CHEK1 | |
| SCHEMBL6514964 | 0.79 | CHEK1 (0.57) | MAPTKDM4EKCNK3KCNK9KMT2A | |
| SCHEMBL6511724 | 0.78 | MAPT (0.51) | MAPTKDM4EKMT2ACHEK1IKBKB | |
| SCHEMBL6507704 | 0.77 | CHEK1 (0.49) | MAPTKDM4EKMT2ACHEK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |