SCHEMBL6510422

SCHEMBL6510422

C#Cc1ccccc1-c1ccc(C#C[Si](C)(C)C)c(N)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.36
KLKB1 P03952 1/20 0.34
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
HPGD P15428 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32
ALOX5AP P20292 1/20 0.31
FEN1 P39748 1/20 0.31
PTPN1 P18031 1/20 0.30
PTPN6 P29350 1/20 0.30
PTPN11 Q06124 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6509952 0.83 AR (0.36) BACE1KLKB1KDM4EMEN1ALDH1A1
SCHEMBL6513126 0.78 FFAR1 (0.35) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL6511906 0.76 ALDH1A1 (0.40) KLKB1KDM4EMEN1ALDH1A1CYP1A2
SCHEMBL6510262 0.73 KDM4E (0.33) BACE1KLKB1KDM4EMEN1ALDH1A1
SCHEMBL3150946 0.73 CYP3A4 (0.52) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL21341026 0.72 BACE1 (0.46) BACE1KDM4EMEN1ALDH1A1CYP1A2
SCHEMBL28815369 0.71 ALDH1A1 (0.48) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL21097451 0.70 GRM5 (0.49) KDM4EMEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL19590795 0.69 ALOX5AP (0.39) BACE1KLKB1ALOX5APFEN1
SCHEMBL9088916 0.69 GRM5 (0.42) BACE1KDM4EMEN1ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050101063-A1 Three-terminal field-controlled molecular devices TOUR JAMES M (US) 2005-05-12 US disclosed
WO-2002035580-A2 THREE-TERMINAL FIELD-CONTROLLED MOLECULAR DEVICES MOLECULAR ELECTRONICS CORPORATION (US) 2002-05-02 WO disclosed